Science that supports our work
At Nanobioactives, the development of nanoparticles and bioactive technologies is based on scientific research, R&D projects and validation in academic and innovation environments.
This section brings together background information that supports the bioactive, functional, and biological properties of our solutions in bone, dental, and other health applications.
Osteogenic and dental properties of bioactive glass nanoparticles:
1. Pardo-Díaz C, Cochinski G, Moreira P, Nascimento FD, Souza Chiari MDE, de Sousa Gomes Costa JL, Covarrubias C, Gutiérrez MF, Loguercio AD, Fernández E. Bioactive and antibacterial universal adhesives containing ZnO/Cu and bioactive glass nanoparticles. J Dent. 2026;167:106524.
👉 https://doi.org/10.1016/j.jdent.2026.106524
2. Pardo-Díaz C, Cochinski GD, Moreira P, Nascimento FD, Chiari MDES, de Sousa Gomes Costa JL, Covarrubias C, Loguercio AD, Fernández E. Effects of ZnO/Cu and bioactive glass-modified universal adhesives on biological properties, bond strength, and interfacial stability under cariogenic challenge. Clin Oral Investig. 2026;30(3):99.
👉 https://doi.org/10.1007/s00784-026-06766-2
3. Cohn N, Bradtmüller H, Zanotto E, von Marttens A, Covarrubias C. Novel organic–inorganic nanocomposite hybrids based on bioactive glass nanoparticles and their enhanced osteoinductive properties. Biomolecules. 2024;14:482.
👉 https://doi.org/10.3390/biom14040482
4. Covarrubias C, Bejarano J, Maureira M, Tapia C, Díaz M, Rodríguez JP, Palza H, Lund F, von Marttens A, Caviedes P, Yazdani-Pedram M. Preparation of osteoinductive–antimicrobial nanocomposite scaffolds based on poly(D,L-lactide-co-glycolide) modified with copper-doped bioactive glass nanoparticles. Polym Polym Compos. 2022;30:1–12.
👉 https://doi.org/10.1177/09673911221098231
5. Maureira M, Cuadra F, Cádiz M, Torres M, von Marttens A, Covarrubias C. Preparation and osteogenic properties of nanocomposite hydrogel beads loaded with nanometric bioactive glass particles. Biomed Mater. 2021;16:045043.
👉 https://doi.org/10.1088/1748-605X/ac0764
6. Corral C, Altamirano D, Maureira M, Martin J, Covarrubias C. Nanoparticles of bioactive glass enhance Biodentine bioactivity on dental pulp stem cells. Materials (Basel). 2021;14:2684.
👉 https://doi.org/10.3390/ma14102684
7. Bejarano J, Boccaccini AR, Covarrubias C, Palza H. Biodegradable PDLLA scaffolds filled with copper- and zinc-doped bioactive glasses for bone repair: effect of metal doping on in vitro bioactivity, mechanical behavior and degradation. Materials (Basel). 2020;13(13):2908.
👉 https://doi.org/10.3390/ma13132908
8. Covarrubias C, Agüero A, Maureira M, Morellia E, Escobar G, Cuadra F, Peñafiel C, von Marttens A. In situ preparation and osteogenic properties of bionanocomposite scaffolds based on aliphatic polyurethane and bioactive glass nanoparticles. Mater Sci Eng C Mater Biol Appl. 2019;96:642–653.
👉 https://doi.org/10.1016/j.msec.2018.11.085
9. Covarrubias C, Cádiz M, Maureira M, Celhay I, Cuadra F, von Marttens A. Bionanocomposite scaffolds based on chitosan–gelatin and nanodimensional bioactive glass particles: in vitro properties and in vivo bone regeneration. J Biomater Appl. 2018;32:1155–1167.
👉 https://doi.org/10.1177/0885328218759
10. Corral Nuñez C, Covarrubias C, Fernandez E, Oliveira OB Jr. Enhanced bioactive properties of Biodentine™ modified with bioactive glass nanoparticles. J Appl Oral Sci. 2017;25:177–185.
👉 https://doi.org/10.1590/1678-77572016-0209
11. Covarrubias C, Mattmann M, von Marttens A, Caviedes P, Arriagada C, Valenzuela F, Rodríguez JP, Corral C. Osseointegration properties of titanium dental implants modified with a nanostructured coating based on ordered porous silica and bioactive glass nanoparticles. Appl Surf Sci. 2016;363:286–295.
👉 https://doi.org/10.1016/j.apsusc.2015.12.022
12. Covarrubias C, Arroyo F, Balanda C, Neira M, von Marttens A, Caviedes P, Urra C. The effect of the nanoscale structure of nanobioceramics on their in vitro bioactivity and cell differentiation properties. J Nanomater. 2015;2015:526230.
👉 https://doi.org/10.1155/2015/526230
Propiedades osteogénicas nanopartículas de litio
Covarrubias C, Durán JP, Maureira M. Facile synthesis of lithium carbonate nanoparticles with potential properties for bone repair applications. Mater Lett. 2018;219:205–208.
👉 https://doi.org/10.1016/j.matlet.2018.02.075
Propiedades antimicrobianas de acrílicos dentales con nanopartículas de cobre
S. Correa, L. Matamala, J.P. González, M. de la Fuente, H. Miranda, B. Olivares, M. Maureira, A. Agüero, L. Gómez, X. Lee, M. Urzúa, C. Covarrubias, Development of novel antimicrobial acrylic denture modified with copper nanoparticles, Journal of Prosthodontic Research, 68(1), 156, 2024.